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WEBSep 25, 2024 · Sigma Gamma Rho Sorority pledges $2M to hospital treating sickle cell. Sigma Gamma Rho Sorority, a national collegiate women’s organization, has committed to raising $2 million by 2028 to support St. Jude Children’s Research Hospital in its efforts to treat children with sickle cell disease (SCD), cancer, and other serious conditions at no …
Stroke rate rising for adults, children with SCD in US: Study
WEB18 hours ago · Among a total of 7,636 patients, the chances of having a first ischemic stroke — caused by a blocked blood vessel — were 2.1% by age 20 and 13.5% by age 60. For intracranial hemorrhage, a type of stroke caused by a burst blood vessel, the chances were 0.5% by age 20 and 6.8% by age 60. While the number of new stroke cases was found …
Top 10 sickle cell disease stories of 2023
WEBJan 2, 2024 · No. 7 – Fewer sickle-shaped red blood cells with gene therapy. The experimental gene therapy BCH-BB694 reduced the number of red blood cells that produce faulty hemoglobin S, the hallmark of SCD. The therapy also curbed the tendency of these cells to take on a sickle-shaped form, as revealed by single-cell data from seven patients …
Vaso-Occlusive Crisis - Sickle Cell Disease News
WEBJan 4, 2022 · A vaso-occlusive crisis, or VOC, occurs when sickled red blood cells block blood flow to the point that tissues become deprived of oxygen. This in turn sets in motion an inflammatory response as the body tries to rectify the problem. The result is substantial pain, which can affect any part of the body, but most commonly occurs in the back ...
Top 10 Sickle Cell Disease Stories of 2022
WEBDec 29, 2022 · Here we’ve compiled a list of the 10 most-read articles published on our site in 2022, with a brief description of each. No. 10 — “ Trial of Cell Therapy to Raise HbF Levels Showing Potential, But Sanofi Leaving ”. SAR445136 is a gene-edited cell therapy designed to boost the production of fetal hemoglobin (HbF) in a patient’s blood ...
FDA meet on exa-cel for SCD complete ahead of approval decision
WEBNov 2, 2023 · Advisory committee focus was on genetic diversity in analysis. The main focus of the advisory committee meeting, according to the FDA’s briefing documents, was assessing the possibility that exa-cel might cause changes in genes other than BCL11A that have a similar genetic sequence. Such off-target genetic changes could potentially …
World Sickle Cell Day supporters seek 'Hope Through Progress' on...
WEBJun 11, 2024 · The theme of this year’s World Sickle Cell Day is “Hope Through Progress: Advancing Care Globally” and supporters are all set to help bring attention to sickle cell disease (SCD), an inherited blood disorder that’s estimated to affect more than 100,000 U.S. residents and 20 million people globally.. Along with raising awareness and funds …
Small molecule shows promise in lab models for treating sickle cell
WEBAug 6, 2024 · Small molecule SR-18292 increased fetal hemoglobin in human blood cells. Sickle cell disease is caused by mutations that lead to the production of an abnormal form of hemoglobin — the protein that red blood cells use to carry oxygen throughout the body. The abnormal hemoglobin tends to clump up inside red blood cells, deforming them into …
Stem cell transplant for sickle cell disease
WEBAug 21, 2024 · A stem cell transplant — also known as a bone marrow transplant, and more formally referred to as hematopoietic stem cell transplantation (HSCT) — is an invasive procedure that can be used to enable people with sickle cell disease (SCD) to produce healthy red blood cells. The bone marrow is home to stem cells, known as …
Stress Can Trigger a Sickle Cell Crisis. Here's How I Avoid It
WEBMar 4, 2020 · The Oxford dictionary defines stress as a “state of mental or emotional strain or tension resulting from adverse or demanding circumstances.” This is what I always understood the meaning of stress to be, but I was unaware of the physical effects that stress can cause to one’s well-being.