LDL receptor - Wikipedia
WEBLDL receptor mediates the endocytosis of cholesterol-rich LDL and thus maintains the plasma level of LDL. [20] This occurs in all nucleated cells, but mainly in the liver which removes ~70% of LDL from the circulation.
The LDL Receptor | Arteriosclerosis, Thrombosis, and Vascular …
WEBApr 1, 2009 · The newly produced LDL receptors remove LDL from the blood, and deliver it to the interior of the cell where the LDL is digested and its released cholesterol becomes available for metabolic purposes.
Biochemistry, LDL Cholesterol - StatPearls - NCBI Bookshelf
WEBAug 8, 2023 · LDL receptor function is needed for the uptake of LDL from the blood into hepatocytes. Defects in LDL receptor function can cause hypercholesterolemia, known as familial hypercholesterolemia, an autosomal dominant disorder.
Low-Density Lipoprotein Internalization, Degradation and Receptor ...
WEBJan 24, 2022 · Low-density lipoprotein (LDL) internalization, degradation, and receptor recycling is a fundamental process underlying hypercholesterolemia, a high blood cholesterol concentration, affecting more than 40% of the western population.
Mechanisms and regulation of cholesterol homeostasis
WEBDec 17, 2019 · Low-density lipoprotein (LDL) receptor (LDLR) and Niemann–Pick type C1-like 1 protein (NPC1L1) both mediate cholesterol uptake from the extracellular sources through the clathrin-dependent...
Low-density lipoprotein receptor--its structure, function, and ...
WEBUptake of cholesterol, mediated by the low-density lipoprotein (LDL)-receptor, plays a crucial role in lipoprotein metabolism. The LDL-receptor is responsible for the binding and subsequent cellular uptake of apolipoprotein B- and E-containing lipoproteins.
LDL Receptor - an overview | ScienceDirect Topics
WEBThe LDL receptor is a transmembrane glycoprotein found on cell surfaces that plays a key role in regulating the uptake of LDL cholesterol into cells, thereby controlling cellular cholesterol levels. AI generated definition based on: Encyclopedia of …
Structure and physiologic function of the low-density lipoprotein receptor
WEBThe low-density lipoprotein receptor (LDLR) is responsible for uptake of cholesterol-carrying lipoprotein particles into cells. The receptor binds lipoprotein particles at the cell surface and releases them in the low-pH environment of the endosome.
The LDL receptor: how acid pulls the trigger - Cell Press
WEBInternalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain
Chasing LDL cholesterol to the bottom — PCSK9 in perspective
WEBJun 15, 2022 · Thus, PCSK9 inhibition augments LDL receptors on the cell surface, where they can bind and clear LDL from the circulation.