Desmosine - Wikipedia
WEBDesmosine is an amino acid found uniquely in elastin, a protein found in connective tissue such as skin, lungs, and elastic arteries. Desmosine is a component of elastin and cross links with its isomer, isodesmosine, giving elasticity to the tissue.
Desmosine as a biomarker of elastin degradation in COPD: …
WEBDesmosine (DES), a cross-link unique to mature elastin, has been extensively discussed as a potentially attractive indicator of elevated lung elastic fibre turnover and a marker of the effectiveness of agents with the potential to reduce elastin breakdown.
Desmosine as a biomarker of elastin degradation in COPD ... - PubMed
WEBDesmosine (DES) and isodesmosine (IDES) are two unusual, tetrafunctional, pyridinium ring-containing amino acids involved in elastin cross-linking. Being amino acids unique to mature, cross-linked elastin, they are useful for discriminating peptides derived from elastin breakdown from precursor elastin peptides.
Desmosine, a biomarker for COPD: old and in the way
WEBDesmosine (this term usually includes the isomer isodesmosine) is a special type of amino acid derived from the condensation of four lysine residues, and is unique to mature, cross-linked elastin molecules.
Desmosine as a biomarker for the emergent properties of …
WEBDec 18, 2023 · Treatment with this agent produced pulmonary emphysema instead of interstitial fibrosis. As a result of their unique presence in elastin and the very low turnover of elastic fibers in normal tissues, DID may potentially serve as a biomarker for lung injury associated with pulmonary emphysema.
Desmosine | C24H40N5O8+ | CID 15942890 - PubChem
WEBDesmosine is an amino acid derivative comprised of three allysyl side chains plus one unaltered lysyl side chain from the same or neighboring polypeptides condensed into a pyridinium ring. Desmosine is found in elastin and its detection in urine, plasma, or sputum samples can be used as a marker for excessive elastin degradation, which is ...
Specific elastin degradation products are associated with poor …
WEBMar 11, 2019 · Desmosine and isodesmosine have long been proposed as biomarkers of lung tissue destruction as they are the crosslinking elements of elastin, released during lung tissue destruction 26.
The role of desmosines as biomarkers for chronic obstructive …
WEBThis paper is aimed at providing a critical review of the methodological steps that have marked the progress in the detection of desmosines in biological fluids in health and disease, as well as the progress in the authors knowledge of desmosines' role in the pathophysiology of COPD.
Desmosine - an overview | ScienceDirect Topics
WEBThe elevated concentration of desmosine in urine was associated with exacerbation episodes in individuals with COPD. Approximately 40% of subjects with exacerbated COPD exhibited increased desmosine levels. 75. The identification of desmosine as a urine biomarker holds promise for the diagnosis and monitoring of COPD.
Desmosine - an overview | ScienceDirect Topics
WEBDesmosine is a positional isomer that crosslink tropoelastin fibers within elastin, a protein that is abundant in the lung. It is hypothesized that when elastin degradation occurs, such as in emphysema, desmosine is released into its …