Anthony Richardson picked up 26.1 fantasy points -- 9-of-19 (47.4%), 212 yards, 2 TDs, 1 INT; 6 carries, 56 yards, 1 TD -- in his best game of the season. That was in Week 1 versus the Houston Texans.

The Indianapolis Colts will need to navigate Week 5 against the Jacksonville Jaguars without their starting quarterback Anthony Richardson. Richardson has been ruled out for this contest and backup quarterback Joe Flacco will start the game.

A banged-up Colts team is likely going to have to break a decade-long drought in Jacksonville without its starting quarterback, in addition to its starting center, best defensive lineman, two starting defensive ends and its best cornerback.