What do the San Francisco 49ers and a cookie have in common? They both crumble when the pressure is on. For the second time this season, the 49ers waste another double-digit lead to lose 24-23 to ...

Seahawks quarterback Geno Smith (7) at Lumen Field for the Week 1 matchup against the Denver Broncos on Sunday, September 8, ...

San Francisco 49ers running back Christian McCaffrey won't return in Week 6, but will likely make his long-awaited comeback by Nov. 10. The latest McCaffrey update is yet another plot twist.

The 49ers have signed DL Jonathan Garvin and WR Terique Owens to the practice squad, released DL Shakel Brown and opened the practice window for DL Kalia Davis. The San Francisco 49ers today ...

The San Francisco 49ers' Jordan Elliot blocked Arizona Cardinals K Chad Ryland's FG attempt & Deommodore Lenoir returns it 61 yards for a TD. National Football League Deommodore Lenoir Jordan ...

The look includes blue helmets with the "D'' on the side featuring ... in the 11-year history at Levi's Stadium, the San Francisco 49ers made a last-minute change to rock their throwback threads.

The San Francisco 49ers have begun to turn the page to their younger players. They signaled those changes in their Week 4 victory against the New England Patriots. Rookie safety Malik Mustapha got ...

Jordan Mason, one of this game's top players to watch, and the San Francisco 49ers face the Arizona Cardinals on Sunday at 4:05 p.m. ET at Levi's Stadium. Don't miss a touchdown this NFL season.

The San Francisco 49ers (2-2) are solid favorites -- expected to win by at least a touchdown (currently -7.5) -- versus the Arizona Cardinals (1-3) in a matchup of two division rivals. The game ...