Researchers used single-cell and spatial genomics to map cell-type-specific changes in the middle temporal gyrus, identifying distinct disease phases in Alzheimer’s progression.

Inside every cell, a network of tiny filaments, called the microtubule cytoskeleton, helps maintain the cell's shape, allows ...

Researchers investigate chromatin conformational and epigenomic reorganization during the development of the prefrontal ...

A new study has created a map of DNA modification in two regions of the brain critical to learning, memory and emotional regulation. The map offers a benchmark for ensuring stem cell-based models ...

This work presents a valuable finding on how the interplay between transcription factors SOX2 and OCT4 establishes the pluripotency network in early mouse embryos. Despite the high quality of the data ...

Researchers suggest findings could help to pinpoint cell types most vulnerable to conditions such as schizophrenia, and ...

Researchers have created a map of DNA modification in two regions of the brain critical to learning, memory and emotional ...

An unparalleled glimpse at how gene regulation changes during human brain development has been provided by a study led by UCLA, which demonstrates the crucial role played by the 3D structure of ...

In mammals, female (XX) and male (XY) cells exhibit sex chromosome dimorphism. To achieve dosage compensation of X-linked ...

Alonso/UCSFFluorescent image of a developing human hippocampus. Key takeawaysA UCLA-led study has created a map of DNA ...