New anti-CKAP4 antibodies deliver hope for pancreatic cancer treatment
This antibody blocks another protein, Dickkopf 1(DKK1), from activating the DKK1–CKAP4, an important pathway that stimulates ...
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Fig.1: DKK1–CKAP4 Signaling and Application of the Anti-CKAP4 Antibody (IMAGE)
DKK1 and CKAP4 are overexpressed in cancer cells and the PI3 kinase–AKT pathway is activated, promoting cell proliferation. Cancer cells secrete CKAP4 in exosomes, and serum CKAP4 is detected by ...
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Angitia Biopharmaceuticals Announces Dosing of First Patient in Phase 2 Clinical Trial of AGA2118 for the Treatment of Osteoporosis
Osteoporosis has become a global epidemic, especially for older women, due to an aging population and longer ... antibody that targets sclerostin and DKK1 and is in clinical development for ...