Aspergillus fumigatus DHN-Melanin - PubMed
WEBDihydroxynaphthalene melanin (DHN-melanin) is an integral component of the conidial cell wall surface, which has a central role in the pathogenicity of the major human airborne fungal pathogen Aspergillus fumigatus.
Recognition of DHN-melanin by a C-type lectin receptor is ... - Nature
WEBFeb 28, 2018 · The C-type lectin receptor MelLec recognizes DHN-melanin in conidial spores of Aspergillus fumigatus and other DHN-melanized fungi, revealing an important role for this receptor in antifungal...
The Enigmatic World of Fungal Melanin: A Comprehensive Review
WEBAug 31, 2023 · Specific to fungal melanin, based on precursors and the pathway taken, the two most significant types of melanin are DHN-melanin (1,8-dihydroxy naphthalene) and DOPA-melanin (L-3,4-dihydroxyphenylalanine) (Figure 1).
Melanin of fungi: from classification to application
WEBAccording to precursor substances of synthetic pathways, fungal melanin can be classified into eumelanin, 1,8-dihydroxynaphthalene (DHN) melanin, pyomelanin, pheomelanin, and 4-Glutaminylhydroxybenzene (GHB) melanin (Table 1).
Melanin triggers antifungal defences - Nature
WEBFeb 28, 2018 · The ability of melanin to target host defences, and the molecule’s role in fungal virulence, raises the question of whether mammalian cells can recognize melanin.
Phagosomal removal of fungal melanin reprograms macrophage ... - Nature
WEBMay 8, 2020 · DHN–melanin is a major determinant of the fungal interaction with the innate immune system 35, endowing A. fumigatus with the ability to survive killing by phagocytes, namely by blocking ...
Two transcription factors cooperatively regulate DHN melanin ...
WEBMay 22, 2019 · Fungal 1,8-dihydroxynaphthalene (DHN) melanin plays important roles in UV protection, oxidative stress and pathogenesis. However, knowledge of the regulatory mechanisms of its biosynthesis is limited.
Identification and Biosynthesis of DHN-melanin Related Pigments …
WEBJan 19, 2023 · In this study, we have identified for the first time the genes involved in the DHN pathway in the three main Monilinia spp. and we have proved their capacity to synthetize melanin-like pigments, both in synthetic medium and in nectarines at three stages of brown rot development.
Raman Characterization of Fungal DHN and DOPA Melanin …
WEBOct 7, 2021 · In this work, we characterize the Raman spectra of wild-type Aspergillus fumigatus and Cryptococcus neoformans and their melanin biosynthetic mutants and provide a rough “map” of the DHN (A. fumigatus) and DOPA (C. neoformans) melanin biosynthetic pathways.
Melanin and pyomelanin in Aspergillus fumigatus: from its genetics …
WEBApr 24, 2019 · DHN-melanin interferes with proteins responsible for the endocytic pathway (e.g., Rab5) preventing phagolysosome fusion, intracellular signaling, and metabolic pathways (e.g., SNARE complex or Rubicon) …