Silyl ether - Wikipedia
WEBSilyl ethers are a group of chemical compounds which contain a silicon atom covalently bonded to an alkoxy group. The general structure is R 1 R 2 R 3 Si−O−R 4 where R 4 is an alkyl group or an aryl group. Silyl ethers are usually used as protecting groups for alcohols in organic synthesis.
Protecting Groups For Alcohols - Master Organic Chemistry
WEBJun 17, 2015 · The most common protecting group for alcohols is silyl ethers.They are easily formed by treating alcohols with R 3 SiCl in the presence of base, and then easily removed with a source of fluoride ion F (-) since Si-F bonds are very strong.
Silyl Radical Activation of Alkyl Halides in Metallaphotoredox ...
WEBJun 6, 2016 · In this report, we demonstrate the use of commercially available tris (trimethylsilyl)silane with metallaphotoredox catalysis to efficiently couple alkyl bromides with aryl or heteroaryl bromides in excellent yields.
Regioselective Ni-Catalyzed reductive alkylsilylation of ... - Nature
WEBNov 19, 2022 · Transition-metal catalyzed carbosilylation of alkenes using carbon electrophiles and silylmetal (-B, -Zn) reagents as the nucleophiles offers a powerful strategy for synthesizing organosilicones,...
Direct allylic C–H alkylation of enol silyl ethers enabled by ...
WEBJun 20, 2019 · Enol silyl ethers, versatile enolate equivalents, are known to undergo one-electron oxidation to generate the radical cations that spontaneously form electrophilic α-carbonyl radicals via...
Ether synthesis by etherification (alkylation) - Organic Chemistry …
WEBA microwave-assisted, chemoselective and efficient method for the cleavage of silyl ethers is catalyzed by Selectfluor. A wide range of TBDMS-, TIPS-, and TBDPS-protected alkyl silyl ethers can be chemoselectively cleaved in high yield in …
Biocatalytic, stereoconvergent alkylation of (Z/E)-trisubstituted silyl ...
WEBNov 2, 2023 · Here we present engineered haemoproteins derived from a bacterial cytochrome P450 that efficiently catalyse α-carbonyl alkylation of isomeric silyl enol ethers, producing stereopure...
Alkylsilane synthesis - Organic Chemistry Portal
WEBIrradiating 3-silyl-1,4-cyclohexadienes with blue light in the presence of a commercially available photocatalyst smoothly generated silyl radicals bearing various substituents. A subsequent trapping by a broad range of alkenes affords products in good yields within 1 h.
Diverse Alkyl–Silyl Cross-Coupling via Homolysis of Unactivated …
WEBFeb 20, 2023 · A wide array of esters and ethers, which are either commercially available or easily synthesized from alcohols participated in the heterogeneous gold-catalyzed silylation by disilanes to give diverse alkyl-, allyl-, benzyl-, and allenyl silanes in high yields.
An Electroreductive Approach to Radical Silylation via the …
WEBDec 12, 2020 · We present a new strategy for silyl radical generation via electroreduction of readily available chlorosilanes. At highly biased potentials, electrochemistry grants access to silyl radicals through energetically uphill reductive cleavage of strong Si–Cl bonds.